Postoperative pain in patients undergoing open surgery
Conditions
Interventions
Group 1:Sufentanil 2µg/ml PCIA
Group 2:Nabuphine 1mg/ml + sufentanil 1µg/ml PCIA
Sponsors
Xijing Hospital Fourth Military Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Open surgery patients; 2. ASA I-II; 3. aged between 18 and 65 years old; 4. BMI between 19 and 29 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Poor compliance, can not cooperate with the surgery; 2. Severe organic disease (coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, abnormal electrolytes); 3. II degree and above atrioventricular block, bradycardia (HR <50 beats / min), hypotension (SBP <90mmHg); 4. History of neurological diseases; history of chronic pain; drug addiction and alcoholism; long-term application of opioids; 5. Patients who are allergic to nalbuphine hydrochloride or components thereof, and patients with allergic history of opioids; 6. Gastric emptying restriction and stomach cramps; 7. Patients with weakened bowel movements or intestinal obstruction; 8. Clinical trial participants who have participated in other drugs in the past 4 weeks; 9. With other circumstances, the investigator believes that it is not suitable for the selected patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS resting and active pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Function score;Total PCA times and PCA effective times;LOS sedation score;Changes in blood pressure, heart rate, respiration, and pulse oxygen;Pain satisfaction;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactDong Hailong
First Affiliated Hospital of Fourth Military Medical University
Outcome results
None listed