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The role of bone microstrcture and microcirculation in the pathogenesis and development of glucocorticoid-induced osteonecrosis of the femoral head

The role of bone microstrcture and microcirculation in the pathogenesis and development of glucocorticoid-induced osteonecrosis of the femoral head

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800020024
Enrollment
Unknown
Registered
2018-12-12
Start date
2019-01-01
Completion date
Unknown
Last updated
2019-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteonecrosis of femoral head

Interventions

Ctrl group:Collect femoral head
glucocorticoid-induced osteonecrosis of femoral head:Collect femoral head
alcohol-induced osteonecrosis of femoral head:Collect femoral head
trauma-induced osteonecrosis of femoral head:Collect femoral head
idiopathic necrosis of femoral head:Collect femoral head
fracture of femoral head:Collect femoral head

Sponsors

Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Patients who underwent hip replacement for necrosis of femoral; (2) Patients who underwent hip replacement for fracture of femoral head.

Exclusion criteria

Exclusion criteria: 1) known metabolic or bone disorders other than osteonecrosis of femoral head, which could affect bone metabolism, such as severe renal impairment, thyroid or parathyroid disease, and malignancy; 2) other known joint diseases, which could affect bone architecture and quality, such as rheumatoid arthritis, Paget disease, congenital hip dysplasia; 3) receiving treatments that affect bone metabolism such as antiresorptive drugs, calcitonin, thyroid or parathyroid hormone therapy, or hormonal replacement therapy; 4) hip osteotomy history.

Design outcomes

Primary

MeasureTime frame
BV/TV;

Countries

China

Contacts

Public ContactLi Guangyi

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

guangyi.li@shsmu.edu.cn+86 15000028837

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026