acute ischemic stroke
Conditions
Interventions
Group 2:saline
Group 1:dexmedetomidine+ulinastatin
Sponsors
Shunde Hospital of Southern Medical University (the first people's hospital of shunde)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. a large number of intracranial vascular occlusion caused by acute ischemic stroke confirmed by CT angiography, no cerebral hemorrhage; 2. aged 18-80 years old, male or female; 3. The informed consent form is signed by the patient or a legal relative; 4. The National Institutes of Health Stroke Scale (NIHSS) scores 6-30; 5. can perform interventional surgery under general anesthesia of tracheal intubation; 6. Start treatment after <8 hours after the onset of symptoms.
Exclusion criteria
Exclusion criteria: 1. Those who are unwilling to continue to receive trial treatment; 2. Patients who were comatose at admission (Glasgow coma score <8) 3. Those who are allergic to related anesthetics; 4. CT confirmed cerebral hemorrhage; 5. Patients with related mental illnesses before surgery, such as: dementia; 6, MRS = 4 before the disease; 7. A history of severe liver disease or severe kidney disease; 8. pregnant women; 9. a history of atrial electrophysiological instability, hemodynamic instability, heart rate below 60 beats / min or systolic blood pressure below 90mmHg. 10. There may be difficulty in intubation or damage to the airway; 11. lost to the visitor; 12. Combine the application of banned drugs or those that affect efficacy evaluation; 13. The original condition deteriorated and the test could not be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NIHSS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow score;TICI grade;MMSE score;Modified Rankin Scale (MRS) score;Barthel index (BI) score;Intraoperative and postoperative complication;Arterial blood gas analysis;Use of Anesthetic drugs (type and total);Adverse reactions; | — |
Countries
China
Contacts
Public ContactZhang Zhongqi
Shunde Hospital of Southern Medical University (the first people's hospital of shunde)
Outcome results
None listed