Helicobacter pylori infection
Conditions
Interventions
Group 1:Full-length sequencing of Hp, simultaneous gastric micro-ecological monitoring
Group 2:Hp in vitro susceptibility test, simultaneous gastric microecology test
Group 3:simultaneous gastric microecology test
Sponsors
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients who have failed to eradicate Helicobacter pylori 2 or more times according to the fifth Chinese Helicobacter pylori diagnosis and treatment guidelines; (2) The criterion for Helicobacter pylori positive is positive for breath test and/or pathologically positive; (3) Aged 18-65 years old male and female; (4) Voluntarily accept the test and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients who have used antibiotics, expectorants, and proton pump inhibitors in the past 1 month; history of major gastrectomy; severe complications such as upper gastrointestinal bleeding and pyloric obstruction; (2) Those with serious primary diseases such as cardiovascular, cerebrovascular, liver and kidney, hematopoietic system, hyperthyroidism, diabetes, etc., or serious diseases (such as tumors) and mental patients that affect their survival; (3) allergic diseases; (4) Pregnancy, or preparation for pregnancy, lactating women; (5) cognitive dysfunction cannot give sufficient informed consent; (6) The investigator believes that there are patients who are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hp full-length gene sequencing;in vitro antimicrobial susceptibility testing;Stomach microecology;Hp serological typing;Pathological HE/GIEMSA staining; | — |
Countries
China
Contacts
Public ContactLin Rong
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed