Effect of NSAIDs on postoperative cognitive function in elderly patients

Effect of parecoxib sodium on postoperative delirium in elderly patients after orthopaedic surgery in intensive care unit

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800019988

Enrollment

Unknown

Registered

2018-12-11

Start date

2019-01-01

Completion date

Unknown

Last updated

2018-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

treatment group:IV parecoxib 40mg

control group:IV saline

Eligibility

Sex/Gender

All

Age

70 Years to 90 Years

Inclusion criteria

Inclusion criteria: Elderly patients aged beyond 70 years old, who will undergo selective orthopaedic surgery,are going to accept postoperative treatment in intensive care unit, regardless of gender.

Exclusion criteria

Exclusion criteria: (1) preoperative delirium; (2) preoperative American Society of Anesthesiologists physical status classification = IV; (3) preoperative congestive heart failure; (4) allergy to nonsteroid anti-inflammatory drugs,or sulfonamide; (5) severe hepatic dysfunction (Child-Pugh score = 10); (6) previous definite ischemic heart disease, cerebrovascular disease or peripheral vascular disease,or after coronary artery bypass grafting; (7) active peptic ulcers or inflammatory bowel diseases.

Design outcomes

Primary

Measure	Time frame
delirum score;	—

Secondary

Measure	Time frame
pain score;	—

Countries

China

Contacts

Public ContactQin Tan

Shanghai Sixth People's Hospital

tanqin@sjtu.edu.cn+86 18930170407

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026