Dry eye
Conditions
Interventions
Group 1:No eye patch
Group 2:Eye patch
Sponsors
Eye Institute of Xiamen University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 40 ~ 80 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the 'dry eye expert consensus' diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 < Schirmer I test (without surface anesthesia) <=10mm/5min. At the same time with conjunctival andcorneal fluorescein staining; 4. Clinical signs andsymptoms of dry eye, clinical examination in accordance with the 'Meibomian gland dysfunction expert consensus' diagnostic criteria (as follows): (1) Abnormal openings of meibomian glands; (2) Abnormal blepharose secretion; (3) Dry eye symptoms); (4) Absence of meibomian gland; (5) Abnormal lipid thickness.5. the choice of study eyes: If patients were treated with both eyes, the eye of the patient with high symptom score was studied.
Exclusion criteria
Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| conjunctival congestion;Corneal staining scores;conjunctival staining scores;naked vision;intraocular pressure;Schirmer Test;TBUT;subjective symptoms;lid margin;meibomian gland assessment;Infrared meibomian gland imaging;lipid layer thickness; | — |
Countries
China
Contacts
Public ContactZuguo Liu
Eye Institute of Xiamen University
Outcome results
None listed