Tuberculosis
Conditions
Interventions
Gold Standard:AFB, BACTEC MGIT 960, Chest imaging examination, histopathology.
Index test:Esat-6, 
CFP-10, 
AG85A, 
CD38 
CD27, 
INF-?.
Sponsors
Shanghai Pulmonary Hospital, Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Initial treatment of tuberculosis group: no history of tuberculosis, chest has the characteristics of tuberculosis, exclude other lung disease, and meet one of the following diagnostic criteria: (1) tuberculosis antibody positive; (2) IGRA positive; (3) PPD strong positive; (4) pathogenic test positive; (5) intralesional lesions pathological tissue or molecular pathological diagnosis of tuberculosis. 2. Initial treatment of extrapulmonary tuberculosis group: no history of tuberculosis, and diagnosis of extrapulmonary tuberculosis, including lymph node Nuclear, bone tuberculosis, tuberculous peritonitis and tuberculous meningitis, without pulmonary lesions, the diagnosis meets relevant standards; 3. Close contacts of tuberculosis: close contacts of newly diagnosed patients with dysentery (more than 6 hours a day, even Continued for two months) and IGRA positive, no active lesions in the lungs and exclusion of extrapulmonary tuberculosis; 4. Non-tuberculosis group: patients with other lung diseases except tuberculosis; 5. Healthy control group: IGRA negative healthy controls.
Exclusion criteria
Exclusion criteria: Primary or secondary immunodeficiency patients, including HIV, long-term use of hormones and patients with immune diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esat-6;CFP-10;AG85A;CD38;CD27;INF-?; | — |
Countries
China
Contacts
Public ContactWei Sha
Shanghai Pulmonary Hospital, Tongji University
Outcome results
None listed