Postreperfusion syndrome
Conditions
Interventions
Experimental group:Infusing terlipressin plus open-label vasopressors to maintain the blood pressure
Control group:Infusing normal saline plus open-label vasopressorse to maintain the blood pressure
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older; 2. Full liver grafts procured from China Donation after Citizen's Death (CDCD) donors; 3. Liver grafts preserved with UW solution and implanted using the standard caval replacement technique without veno-venous bypass; 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to vasopressin or its analogs (e.g., vasopressin, terlipressin, or pituitrin); 2. Severe cardiopulmonary disease (e.g., angina, myocardial infarction, heart failure, moderate-to-severe pulmonary hypertension, or pulmonary heart disease); 3. Primary kidney disease (e.g., nephritis, azotemia, or renal failure); 4. Septic shock; 5. Required preoperative vasopressor support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of severe PRS;PV flow velocity of the new liver graft; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complications;Hemodynamic parameters;Usage of vasopressors;Serum AVP levels; | — |
Countries
China
Contacts
Public ContactZhang Liang
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed