Gastroesophageal reflux related diseases
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
17 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Regurgitation as the chief complaint may accompanied by other symptoms such as heartburn, dysphagia, nause, vomiting, respiratory symptoms( pharyngalgia, cough, wheeze, chronic rhinosinusitis and so on unexplained by primary common diseases), etc; 2. the presence of regurgitation symptoms, sleep disturbances and use of over-the-counter medications five to seven days a week; 3. completed endoscopy before manometry; 4. no response to full dose PPIs treatment for 8-12weeks. Endoscopic positive presentation: high-grade oesophagitis (LA grades C or D), Barretts oesophagus or peptic stricturing.
Exclusion criteria
Exclusion criteria: 1. Used any medications that may contribute to upper gut symptoms such as: aspirin/NSAIDs, anticholinergic agents, calcium channel blockers, nitrates[2]; 2. have a history of previous upper gastrointestinal surgery; 3. pregnant women [4]; 4. accompanied by malignant cancer, ulcers, heart and primary lung disease and severe local infection, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| low esophageal sphincter pressure;integrated relaxation pressure;the length of low esophageal sphincter;upper esophageal sphincter pressure;residual pressure of UES;the length of upper esophageal sphincter;diatal contractile itegral; | — |
Countries
China
Contacts
Public ContactZhijun Duan
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed