Local advanced nasopharyngeal carcinoma
Conditions
Interventions
Intervention group:Intravenous infusion of calcium folinate started 3 days before chemotherapy
Control group:Without calcium folinate
Sponsors
the Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Nasopharyngeal carcinoma (NPC) was diagnosed by pathology at the age of 18-70. Its clinical stage was locally advanced (stage III or IVa); 2. No antineoplastic treatment before; 3. The survival time more than 3 months; 4. Patients'whole body state score should be less than 2 points according to ECOG (Eastern Cooperative Oncology Group) score; 5. The patient must meet all of the following conditions: white blood cell count at 4,000-10,000/mm3; neutrophil count at or above 2,000/mm3; platelet count at or above 100,000/mm3; hemoglobin at or above 11.0 g/dL; aspartate aminotransferase (AST) and alanine aminotransferase (ALT) = 1.5 times the upper limit of normal value; total bilirubin at or below 24 umol/L and creatinine at or below 85umol/L.
Exclusion criteria
Exclusion criteria: 1. Distant metastasis in clinical stage (M1); 2. Malignant tumors were diagnosed and treated with radiotherapy and chemotherapy within 5 years before admission; 3. There are the following serious diseases: uncontrollable infections, severe heart failure and myocardial infarction in the past six months; 4. pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| white blood cell;platelet;Glutamic pyruvic transaminase;glutamic-oxalacetic transaminase;creatinine; | — |
Countries
China
Contacts
Public ContactHuaili Zhou
Department of thoracic oncology, the cancer center of the fifth affiliated hospital of Sun Yat-sen University
Outcome results
None listed