FindTrial
Sign In

Effect of preoperative morphine preconditioning on myocardial ischemia-reperfusion injury after cardiopulmonary bypass in patients with chronic heart failure and its signaling mechanism of Cav-3/MG53

Effect of preoperative morphine preconditioning on myocardial ischemia-reperfusion injury after cardiopulmonary bypass in patients with chronic heart failure and its signaling mechanism of Cav-3/MG53

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800019895
Enrollment
Unknown
Registered
2018-12-07
Start date
2018-12-10
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic heart failure

Interventions

Group 1:Morphine preconditioning
Group 1:Placebo

Sponsors

The Second Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with chronic heart failure undergoing elective surgery for valve replacement during cardiopulmonary bypass; 2. Age > 18 years old male and female; 3. Body mass index (BMI) 18~30 kg/m2; 4. ASA is graded II to IV; 5. Get informed consent from patients and/or their families.

Exclusion criteria

Exclusion criteria: 1. The history of opioids addiction; 2. Patients with cardiomyopathy with unexplained causes; 3. Diabetes and obese patients; 4. Serious mental illness cannot be matched; 5. Patients with severe respiratory diseases and liver and kidney failure.

Design outcomes

Primary

MeasureTime frame
Echocardiography;cardiac troponin I;Post-operative myocardial infarttion;Stroke;—

Secondary

MeasureTime frame
Blood lactic acid;Post-operative renal injury;—

Countries

China

Contacts

Public ContactZhang Ye

The Second Hospital of Anhui Medical University

zhangye_hassan@sina.com+86 0551 63869480

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026