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Correlation and mechanism between vitamin D and intestinal epithelial barrier protein in children with inflammatory bowel disease

Correlation and mechanism between vitamin D and intestinal epithelial barrier protein in children with inflammatory bowel disease

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800019881
Enrollment
Unknown
Registered
2018-12-05
Start date
2018-12-03
Completion date
Unknown
Last updated
2018-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inflammatory bowel disease in pediatric

Interventions

inflammatory bowel disease group:nonintervention
health group:No intervention

Sponsors

Beijing Children's Hospital Affiliated to Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Children with inflammatory bowel disease diagnosed in the digestive department of Beijing children's hospital. Healthy children were also selected as the control group.

Exclusion criteria

Exclusion criteria: 1. Patients with rickets, diabetes, renal diseases, parathyroid diseases and vitamin D metabolic disorders; 2. Taking drugs such as hormones and phenobarbital that affect vitamin D absorption recently; 3. Have other intestinal diseases.

Design outcomes

Primary

MeasureTime frame
Serum vitamin D concentration;Intestinal epithelial vitamin D receptor;Intestinal occludin protein;Intestinal claudin-1 protein;Intestinal TCPTP protein;Intestinal p-JAK1 protein;Intestinal p-stat3 protein;—

Secondary

MeasureTime frame
Intestinal JAK protein;intestinal stat3 protein;—

Countries

China

Contacts

Public ContactXiwei Xu

Beijing Children's Hospital Affiliated to Capital Medical University

xuxiweibch@163.com+86 13370115010

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026