herpes zoster-associated pain
Conditions
Interventions
Group A:Oral pregabalin treatment for herpes zoster-associated pain
Group B:Hydromorphone patient-controlled intravenous analgesia combined with oral pregabalin treatment for herpes zoster-associated pain
Sponsors
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Subjects must meet the diagnostic criteria for herpes zoster associated pain and the pain present for =1 months; 2. Male or female subjects aged 50 years and above; 3. Before admission, subjects have received antiviral, oral opioids and nerve block treatment, with unsatisfied pain controll, which defined as the average pain level =40 mm on a 100 mm visual analog scale (VAS slide ruler); 4. Subjects without neurological dysfunction; 5. Subjects who can understand and fill out various rating scales; 6. Subjecys is voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects with severe heart, lung and kidney dysfunction; 2. Subjects with coagulopathy; 3. Subjects with cognitive dysfunction or poorly matched; 4. Subjects with allergic constitution or a history of drug sensitivity similar to the study drug structure; 5. Subjects with contraindications to test drugs (respiratory depression, paralytic ileus, and unconsciousness); 6. Subjects with a history of drug abuse; 7. Subjects with mental disorders or those who have been judged by the investigator are considered unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain assessment;Pain assessment;Pain assessment;Sleep quality assessment;Quality of life assessment;PGIC; | — |
Countries
China
Contacts
Public ContactLin Jian
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed