acute pancreatitis
Conditions
Interventions
AR group:Acetated Ringer's sodium intravenous injection 1000 ml per 24, initiated within 24 h after admission sustaining for 3 days
LR group:Lactated Ringer's solution intravenous injection 1000 ml per 24, initiated within 24 h after admission sustaining for 3 days
NS group:Normal Saline intravenous injection 1000 ml per 24 hours, initiated within 24 h after admission sustaining for 3 days
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with acute pancreatitis who meet the new classification criteria for Atlanta (2012 revision); 2. hospital admission within 72 hours of disease onset; 3. patients between the ages of 18 and 70 years.
Exclusion criteria
Exclusion criteria: (1) cardiovascular disease (greater than New York Heart Association class II heart failure, active myocardial ischemia or cardiovascular intervention within previous 60 days); (2) chronic kidney disease (uremia or hematodialysis); (3) pregnancy pancreatitis; (4) cancer; (5) diabetic ketoacidosis; (6) severe cerebral edema; (7) hepatosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of SIRS at 24h, 48h and 72h after admission;mortality within 30 days;MCTSI score; | — |
Secondary
| Measure | Time frame |
|---|---|
| infusion volume of the first three days;hour-urine output for the first three days;the serum concentration of inflammatory markers (IL-6, IL-10, CRP,TNF-a) for the first 3 days;indicators of liver and kidney function; | — |
Countries
China
Contacts
Public ContactWenfu Tang
West China Hospital, Sichuan University
Outcome results
None listed