Alzheimer’s Disease
Conditions
Interventions
Sponsors
The Sixth Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: For NC subjects, they had global Clinical Dementia Rating (CDR) scores of 0 and Mini-Mental State Examination (MMSE) scores between 24 and 30. NC subjects were required not to have experienced memory loss. For patients diagnosed with aMCI, fulfilling the Petersen criteria for aMCI, they had global CDR scores of 0.5 and MMSE scores between 24 and 30. And they had the following features: 1) subjective memory complaints; 2) episodic impairment on standard neuropsychological tests; 3) preservation of basic activities in daily life; 4) absence of significant impairment in more than 2 cognitive domains; 5) absence of dementia according to Diagnostic and Statistical Manual of Mental Disorders 2013; 6) absence of anxiety disorders or mood disorders. For patients diagnosed with AD, fulfilling the DSM-V criteria for dementia, they had global CDR scores between 0.5 and 2 and MMSE scores down 24. AD patients were also classified based on the criteria of the National Institute on Aging-Alzheimers Association 2011.
Exclusion criteria
Exclusion criteria: Presence of other neurological, cerebrovascular (such as transient ischemic attack, stroke or intracranial hemorrhage), psychiatric (such as depression, schizophrenia or paranoid psychosis), medical or metabolic disorders that might interfere with the study. Participants who had Hachinski Ischemia scores greater than 4, obesity (BMI=25), and history of alcoholism or drug abuse were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality;Sex hormone plasma levels;Macular degeneration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pupil;Cerebrospinal fluid Aß, t-tau, p-tau levels; | — |
Countries
China
Contacts
Public ContactZhong Li
Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed