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Clinical study for the efficacy and safety of A botulinum toxin in the treatment of depression

Clinical observation for the efficacy and safety of A botulinum toxin in the treatment of depression: a randomized, double blind, controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800019802
Enrollment
Unknown
Registered
2018-11-30
Start date
2018-01-01
Completion date
Unknown
Last updated
2018-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depressive disorder

Interventions

Intervention group:antidepressant +BTX-A
Control group:antidepressant +Normal saline

Sponsors

The Second Hospital Affiliated to Suzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) all the patients were consistent with the standard of depression in DSM-IV; (2) Aged 18-75 years; (3) Hamilton Depression Scale (17 items): 7 points less than or equal to 24 or less were divided; (4) right-handed, emmetropia

Exclusion criteria

Exclusion criteria: (1) the patients with other psychiatric disorders other than depression; (2) the patients with other systemic diseases and brain organic diseases caused by depression; (3) with a history of head disease, brain injury, epilepsy and other nervous system diseases; (4) with a history of severe cardiovascular system the respiratory system, immune system and systemic disease history; (5) with a history of alcohol, morphine or drug abuse; (6) patients with liver and kidney dysfunction; (7) to cooperate with the completion of the relevant neuropsychological tests; (8) the period and lactation of pregnant women, are not involved in the study.

Design outcomes

Primary

MeasureTime frame
Hamilton Depression Scale;Self-rating Depression Scale;

Secondary

MeasureTime frame
Short Form 36 health survey;Hamilton Anxiety Scale;Self-rating Anxiety Scale;

Countries

China

Contacts

Public ContactLuo Weifeng

The Second Hospital Affiliated to Suzhou University

lwfwxx@126.com+86 13814841508

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026