The metagenomic analysis of oral microflora in patients with primary Sjogren's syndrome before and after caries treatment and topical fluoridation

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1800019784

Enrollment

Unknown

Registered

2018-11-28

Start date

2018-12-01

Completion date

Unknown

Last updated

2018-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary Sjogren's syndrome, dental caries

Interventions

caries-active group:topical fluoridation

caries treatment

caries-inactive group:topical fluoridation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. diagnosed with primary Sjogren's syndrome according to the revised 2002 international classification criteria by the Department of Oral Medicine of Peking University School and Hospital of Stomatology; 2. Beijing residents; 3. have no allergy history; 4. All subjects were informed and agreed to participate in the study.

Exclusion criteria

Exclusion criteria: 1. have xerostomia symptoms but not fulfilling the criteria; 2. have diabetes mellitus; 3. have other autoimmune diseases; 4. have received radiotherapy; 5. have taken drugs with side effects of dry mouth for 3 months; 6. have oral mucosal lesion during sampling; 7. have fluoride exposure in 3 months.

Design outcomes

Primary

Measure	Time frame
DMFT/DMFS;oral microflora;	—

Countries

China

Contacts

Public ContactXiaochi Chen

Peking University School and Hospital of Stomatology

chen_xiaochi@126.com+86 13911117213

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026