patients with non-mechanical ventilation in ICU
Conditions
Interventions
Group 1:Nalbuphine
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. CPOT scores>=3 points; 2. patients with non-mechanical ventilation in ICU; 3. Aged 18 to 75 years old.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation; 2. general anesthesia surgeon within 48 hours; 3. Severe, existing substantial liver disease with clinically significant portal hypertension, Child-Pugh C cirrhosis or acute liver failure; 4. bronchial asthma or COPD, myasthenia gravis patients; 5. severe craniocerebral injury, brain tumor, increased intracranial pressure and other susceptible to respiratory depression in patients; 6. patients with a history of alcohol or drug abuse; 7. Any condition that prevents proper assessment of cognitive function, such as language and sensory impairment or mental disorder (language difficulties or mental organic dysfunction); 8. unable to obtain informed consent or authorization; 9. participate in other exploratory clinical trials within 6 months prior to screening; 10. allergic to nalbuphine or fentanyl.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CPOT score; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS score;CAM-ICU score;Incidence of adverse reactions;APACHEII score;SOFA score;biochemical index;routine blood examination;arterial blood gas analysis; | — |
Countries
China
Contacts
Public ContactTongwen Sun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed