Skip to content

Effects of sedative and analgesic drugs on gastrointestinal motility in patients with craniocerebral injury

Effects of sedative and analgesic drugs on gastrointestinal motility in patients with craniocerebral injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800019720
Enrollment
Unknown
Registered
2018-11-25
Start date
2018-07-01
Completion date
Unknown
Last updated
2018-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

craniocerebral injury

Interventions

Case series:dexmedetomidine, midazolam, propofol, remifentanil and caffeine

Sponsors

The First Affiliated Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) admitted to Department of Neurosurgery ICU, aged 18 to 90 years old; (2) feeding through nasogastric tube can tolerate the infusion speed of 40Kcal/h nutrient solution; (3) Sedative and analgesic needs, and daily wake-up: patients with RASS score greater than 1, self-expression, NRS score greater than or equal to 4, patients with no communication, BPS score greater than or equal to 5 or CPOT score greater than or equal to 3, or delirium evaluation CAM-ICU positive, sympathetic excitement seizures, etc.

Exclusion criteria

Exclusion criteria: 1. we need hibernation mixture and continuous sedation; 2. Operations to change the pyloroduodenal anatomy were performed on the esophagus, stomach and pancreas (e.g. Whipple operation); 3. Satisfactory gastric antrum ultrasound images can not be obtained due to upper abdominal wound, obesity or abdominal distention; 4. pregnant women; 5. Prone position ventilation needs.

Design outcomes

Primary

MeasureTime frame
Amplitude of antral contraction;Gastric antral contraction frequency;motility index;

Secondary

MeasureTime frame
Bowel sounds;

Countries

China

Contacts

Public ContactOuyang bin

The First Affiliated Hospital of Sun Yat-Sen University

13501549273@163.com+86 13501549273

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026