depression
Conditions
Interventions
A:Pseudo stimulus bid
B:tDCS 2mA qd+Pseudo stimulus qd
C:tDCS 3mA bid
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The fourth edition of the Handbook of Diagnostic and Statistical Disorders of the American Psychiatric Association(Diagnostic and Statistical Manual of Mental Disorders, DSM-4) Diagnostic criteria for depression; (2) Hamilton Depression Scale, (HAMD-17) =17; (3) Aged 18-65 years (when obtaining informed consent), right-handed, male or female; (4) Written informed consent of the subject and family members.
Exclusion criteria
Exclusion criteria: (1) Exclusion of other axis I mental disorders other than depression by interview with the MINI-International Neuropsychiatric Interview (M.I.N.I.); (2) those with acute or chronic renal failure; those with cirrhosis or active liver disease; (3) The laboratory examination is abnormal and judged to have clinical significance, and the researcher believes that it affects the efficacy or shadow of the test.Responding to the safety of the subject; (4) suffering from serious or unstable physical diseases, including: nervous system diseases (sputum, dementia, stroke, epilepsy, migraine, high intracranial pressure, brain surgery, etc.), congestive heart failure, angina pectoris, myocardial infarction, Arrhythmia, hypertension (including untreated or uncontrolled hypertension), apnea syndrome, malignancy, immunocompromised subjects, and subjects with blood glucose above 12 mmol/L; (5) Alcohol or drug dependence within 3 months before the start of the trial or 6 months before the trial; (6) Pregnant women, lactating women, women of childbearing age who were positive for urine HCG test during screening period. male,Female subjects did not take effective contraceptive measures, or plan to receive (grant) pregnant women within 3 months after the start of the trial; (7) There are strokes in the past one month; (8) Family history of epilepsy (referring to two or three generations); (9) Skin skull condition: abnormal placement of the electrode, if there is an open wound; (10) Those, who are unable to receive fMRI, such as claustrophobia patients (subjects only for functional magnetic resonance imaging); (11) The investigator believes that there are other conditions that are not suitable for participating in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy;Side-effect;magnetic resonance imaging.; | — |
Countries
China
Contacts
Public ContactWu Hong
Shanghai Mental Health Center
Outcome results
None listed