chronic wounds
Conditions
Interventions
experimental group:Antibacterial protease
Sponsors
Drum Tower Hospital Affiliated to Nanjing University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Comply with the chronic wound diagnosis standard proposed by the Chinese Medical Association Trauma Branch in 2011 (ie, a wound that has not healed for more than one month and has no healing tendency); in the case of diabetes, blood glucose control is normal and stable in the past 2 weeks; (2) Comply with 6 clinical judgment standards in accordance with the existence of bacterial biofilm released in 2016: 1 wound bed with pale edema; 2 fragile granulation tissue; 3 large yellow exudate; 4 necrotic decay tissue; 5 wound pain; Have a rancid smell; (3) Aged at least 18 years old male and female; (4) Voluntarily participate in clinical research and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) accompanied by severe heart, lung, kidney and liver complications or critical illness, life-threatening conditions such as shock; (2) patients with bleeding disorders or bleeding tendency, patients with malignant tumors; organ transplant wounds; (3) Chronic wounds secondary to systemic infections or other infections requiring antibiotic treatment or antibiotics; (4) pregnant women or lactating women; combined with mental illness, can not cooperate; (5) The primary disease has an autoimmune disease or is taking hormones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of wound volume;PUSH score; | — |
Secondary
| Measure | Time frame |
|---|---|
| temperature;PH;The bacterial extracellular matrix of wound and the decrease rate of bacteria; | — |
Countries
China
Contacts
Public ContactWEI MIN
Nanjing University Medical School
Outcome results
None listed