Breast Cancer
Conditions
Interventions
Case series:Neoadjuvant chemotherapy regimen containing anthracycline and taxol
Sponsors
Southwest Hospital, Army Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years old; histologically confirmed invasive ductal carcinoma of the breast; suitable for neoadjuvant chemotherapy; 2. Initial treatment; life expectancy greater than 3 months; patient must have the ability to understand and voluntarily sign informed consent; 3. The ECOG physical status score was 0 to 2; there was at least one definite measurable tumor lesion (according to RECIST criteria, using conventional techniques, lesion diameter (> 20 mm), or spiral CT (> 10 mm); 4. Subjects had no major organ dysfunction, and laboratory test indicators must meet the following requirements: (1) Leukocyte (> 3.5 * 10^9/L), neutrophil (> 2.0*10^9/L), platelet count (> 100*10^9/L), hemoglobin (> 95 g/L); (2) Liver function: serum bilirubin is 1.5 times the maximum normal value; (3) ALT and AST were 1.5 times lower than the maximum normal value; (4) Renal function: creatinine clearance rate is more than 45mL/min; (5) Cardiac function: normal.
Exclusion criteria
Exclusion criteria: 1. With other malignancie; 2. Through various channels to accept new target drug therapy which not listed in China; 3. Under the image, the channel (puncture path) is not clear and unclear; 4. Serious impairment of liver function and renal functionsevere heart failure; 5. Combined with active infection; 6. There are uncorrectable coagulation disorders and obvious hemogram abnormalities with obvious bleeding tendency; 7. Patients who can not be treated on time for various reasons; 8. The researchers concluded that other causes were not appropriate for clinical trials: a history of craniocerebral injury or trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall response rate;pCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease free survival;overall survival; | — |
Countries
China
Contacts
Public ContactXiaowei Qi
Southwest Hospital, Army Medical University
Outcome results
None listed