Type 2 diabetes
Conditions
Interventions
Case series:Fortified vitamin k2 yogurt
Control series:yogurt
Sponsors
Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 40-70 years old (the age is calculated according to the difference between the screening survey date and the date of birth), with type 2 diabetes confirmed by community hospital and with clear disease history 2. Patients with no serious diabetic complications, such as leg ulcers, severe liver and kidney damage, severe neurological diseases, severe retinopathy, etc.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Alcoholism (drinking more than 5 times a week, an average of 2 two white wines or half a catty of yellow wine or more than 5 bottles of beer); 3. Suffering from a serious mental illness in the past 6 months; 4. In the past 3 months, patients who received medical treatment for the following diseases: cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, cystitis, hyperthyroidism and other thyroid dysfunction; 5. Have undergone gastrointestinal surgery, except for appendicitis and hernia surgery; 6. Chronic, prolonged hepatitis patients, patients with severe liver disease such as cirrhosis or hepatitis B virus surface antigen (HBsAg) positive with abnormal liver function (serum alanine aminotransferase and aspartate aminotransferase is 2.5 times normal); 7. suffering from IBD, Cushing syndrome; 8. suffering from pituitary dysfunction; 9. Suffering from serious organic diseases such as cancer, coronary heart disease, myocardial infarction and stroke; 10. Have infectious diseases such as tuberculosis and AIDS; 11. Physical disability, or other causes of life can not take care of themselves, can not clearly recall, answer questions; 12. In the past 3 months, any medicine (including appetite inhibitors such as fluoropropionamide and thyroid hormones, progesterone, laxatives, etc. and various Chinese medicine ingredients diet pills) or surgical methods for weight loss; antibiotics used in the past 3 months; 13. There are obvious movement disorders; 14. There is no guarantee of sufficient time to participate in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glycosylated hemoglobin;fasting glucose;serum dp-ucMGP;fasting insulin;gut microbiota; | — |
Countries
China
Contacts
Public ContactLi Ying
Harbin Medical University
Outcome results
None listed