Tuberculosis
Conditions
Interventions
Intervention group A:Drug A: Isoniazid, adults: Weight=50kg, 600mg, weight=50kg, 500mg
Children: no more than 300mg(10~15mg/kg), twice weekly for 24 doses.Drug B: Rifapentine, adults: Weight=50kg, 600mg, weight=50kg, 450mg
Children aged more than 5: 10~20mg/Kg, no more than 450mg, twice weekly for 24 doses.
Intervention group B:Isoniazid, Daily for 180 doses.Dosage: adults: 300mg/dose, children: no more than 300mg/dose(10mg/kg).
Not taking medicine group C (Not taking medicine for any reason):No interventons
Sponsors
Chinese center for disease control and prevention
Eligibility
Sex/Gender
All
Age
5 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Local household registration or resident population; 2. aged between 5-65 years; 3. Signed voluntarily informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous and current tuberculosis patients; 2. Index case is rifampicin and/or isoniazid-resistant tuberculosis; 3. Pregnant or lactating or preparing for pregnancy; 4. Alcohol/drug addicts; 5. Mental disorders, deaf/mute disabled who can not cooperate with the study; 6. HIV-infected or AIDS; 7. HCV infection; 8. A history of treatment for > 14 consecutive days with a rifapentine or > 30 consecutive days with INH at any time during the 2 years prior to enrollment; 9. Contraindications for taking isoniazid including abnormal liver function, mental disorder patients, patients with epilepsy; 10. Contraindications for taking rifapentine/rifampin: those who are allergic to rifampicin/rifamycin-based antibacterials, severe abnormal liver function, biliary obstruction, and pregnant women; 11. Liver disease (ALT or AST > two times normal limit, or total bilirubin > 1.5 times normal limit, or/and with clinical evidence of hepatic damage; 12. Renal inadequacy or diminished; 13. White blood count (WBC) < 2.0×10^9/L; 14: Past Cirrhosis; 15. Past epilepsy; 16. Others.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Advent of active pulmonary tuberculosis; | — |
Countries
China
Contacts
Public ContactZhang Hui
Chinese center for disease control and prevention
Outcome results
None listed