Pediatric protracted bacterial bronchitis
Conditions
Interventions
higher dose group:45 mg/kg amoxicillin-clavulanate twice a day
standard dose group:30 mg/kg amoxicillin-clavulanate twice a day
Sponsors
The second affiliated hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Male
Age
0.5 Years to 6 Years
Inclusion criteria
Inclusion criteria: Eligible subjects of this study are patients who visit the second affiliated hospital & Yuying childrens hospital because of chronic wet cough during the study period. inclusion criteria: 1. Subjects or their guardians agree to participate in this study; 2. Six months to 6 years old; 3. Diagnosed as protracted bacterial bronchitis (PBB) after screen tests; 4. Definition of PBB: 1) Presence of continuous wet chronic (>4 weeks duration) wet or productive cough; 2) Detect lower respiratory bacterial infection evidence in bronchoalveolar lavage (BALF) culture, bacterial loads?105 CFU.mL-1; 3) There is no evidence of pertussis, mycoplasma pneumoniae or chlamydia infection (According to PCR or serological examination); 4) Absence of symptoms or signs (i.e. specific cough pointers) suggestive of other causes of wet or productive cough.
Exclusion criteria
Exclusion criteria: 1. Serious neurological underdevelopment; 2. Patients with basic diseases: such as neuromuscular diseases, immune deficiency, malnutrition, heart diseases, congenital respiratory deformity, heart, brain, liver, kidney and blood system diseases, and genetic metabolic diseases; Liver function indictors (ALT, AST) more than 2 times the normal value, renal function indictor more than the normal upper limit; 3. Has received more than two weeks treatment of antibiotics; 4. Allergic to penicillin, with fever or pneumonia; 5. Poor compliance, expected difficult to complete the study; 6. With other conditions that the researcher consider inappropriate for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate; | — |
Countries
China
Contacts
Public ContactZhang Hai-Lin
The second affiliated hospital of Wenzhou Medical University
Outcome results
None listed