Postoperative recovery and respiratory function
Conditions
Interventions
Group 1:Intraoperative sedation with dexmedetomidine
Group 2:Intraoperative sedation with propofol
Sponsors
Department of anesthesiology, the Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40 to 65 years old; 2. ASA score I, II; 3. Voluntarily consent to participate the study 4. Scheduled to recieve hip and knee surgery under monitored anesthesian care
Exclusion criteria
Exclusion criteria: 1. Seondary surgery during the study 2. Be allergic to alpha-2 receptor agonistsuch as dexmedetomidine 3. History of drug abuse, alcohol or opioid abuse; 4. Other experimental drugs or other clinical trials were taken in the first three months of the study; 5. Combined with bradyarrhythmia or serious heart, brain, liver, kidney and hematopoietic system; 6. Unable to cooperation with the study procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qor-15;Tidal volume;Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delirium;VSH sleep scores;Postoperative satisfaction scores;Postoperative pain NRS;Time to feel pain; | — |
Countries
China
Contacts
Public ContactHong LI
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed