premature ovarian insufficiency
Conditions
Interventions
Case series:autologous transplantation of MenSCs
Sponsors
Shengjing Hospital affiliated to China Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Woman aged from 20 to 40 years old; 2. Oligo/amenorrhea for at least 4 months; 3. An elevated FSH level>25 IU/l on two occasions > 4 weeks apart; 4. Routine treatment including hormone replacement therapy and non-hormone replacement therapy (phytoestrogens, traditional Chinese medicine acupuncture) have limited effect on POI.
Exclusion criteria
Exclusion criteria: 1. Genital tuberculosis; 2. Chronic debilitating or hemorrhagic diseases; 3. Chromosomal abnormal; 4. Postoperation of malignant ovarian tumor; 5. Chocolate cyst of ovary; 6. Infertility factors such as uterine factors ( myoma of uterus, adenomyosis and hydrosapinx) and factors affecting embryo implantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| antral follicle count;improvement in hormone levels (AMH, FSH, LH, E2); | — |
Secondary
| Measure | Time frame |
|---|---|
| menstrual cycle;ultrasound;egg number;pregnancy rate;live birth rate; | — |
Countries
China
Contacts
Public ContactJichun Tan
Shengjing Hospital affiliated to China Medical University
Outcome results
None listed