Polycystic ovary syndrome
Conditions
Interventions
letrozole second dose after non-response to initial letrozole dose:Letrozole 2.5mg/d(BMI=25kg/m2), 5mg/d(BMI>25kg/m2), for cycle day 3 to 7
Letrozole 5mg/d(BMI=25kg/m2),7.5mg/d(BMI>25kg/m2) , for cycle day 9 to 11
HCG 10000u on day of trigger
Gonadotropin group:Letrozole 2.5mg/d(BMI=25kg/m2), 5mg/d(BMI>25kg/m2), for cycle day 3 to 7
HMG/rFSH 75u/d, for cycle day9 to 11,if response continued same dose until day of trigger, if no response HMG/rFSH 112.5u from cycle day12 to 14, if response continued same dose until day of trigger
Sponsors
Shenzhen Maternity and Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
21 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. aged 21-40 years; 2. according to two of the three following criteria: no ovulation (irregular menstrual cycle, ); high androgen levels (serum testosterone >/=0.75ug/L) and/or clinical signs of androgen excess; polycystic ovaries (>/=12 antral follicles in every ovary); 3. at least 1 year of infertility till recruit; 4. at least one open fallopian tube and a normal uterine cavity confirmed by HSG, ultrasonography, laparoscopy and/or hysteroscopy.
Exclusion criteria
Exclusion criteria: 1. suffer from other uncontrolled endocrine disease that might cause infertility, such as hyperthyroidism or congenital adrenal hyperplasia; 2. suffer from other gynecologic disease that might cause infertility, such as endometriosis or adenomyosis; 3. severe organ dysfunction or mental illness; 4. BMI >30 would recommend 5% weight loss before recruit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ovulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum human chorionic gonadotropin level; | — |
Countries
China
Contacts
Public ContactLI Xuemei
Shenzhen Maternity and Child Healthcare Hospital
Outcome results
None listed