hepatocellular carcinoma with portal vein tumor thrombus
Conditions
Interventions
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patient aged 5 years to 80 years male or female; 2. patient was pathological or clinical diagnosed with hepatocellular carcinoma with portal vein tumor thrombus; surgical evaluation revealed that the primary lesion was unresectable and the patient had no distant metastasis; 3. According to PVTT, the patients with type II and III, that is, tumor thrombus involving the portal trunk and first grade branches; 4.Child-Pugh liver function rating: A or better B level (less than 8 points); 5. ECOG PS score: 0-2 6. Main organs are functioning normally,conform to the following criteria: (1) Blood tests: HB=90g/L; ANC=1.5×10^9/L; PLT=70×10^9/L; (2) Biochemical examination: ALB=28g/L; ALT?AST=5ULN; TBIL=1.5ULNd; Cr=1.5UL; 7. Participants voluntarily joined the study, signed informed consent, and had good compliance and follow-up.
Exclusion criteria
Exclusion criteria: 1. Poor physical condition, PS score 3-4; 2. Child-Pugh liver function rating: C level; 3. Huge tumors, hypersplenism, hepatic encephalopathy, massive ascites or extensive abdominal metastasis; 4. Active gastric ulcer and severe esophagogastric varices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Over all survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective Response Rate, ORR;Objective Response Rate, ORR;Disease control rate (DCR);Progression-free survival (PFS);Toxic and side effects;Quality of life (QOL); | — |
Countries
China
Contacts
Public ContactXue Jun
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed