Tetralogy of Fallot
Conditions
Interventions
Conventional treatment group:Childen did not receive an antifibrinolytic agent during surgery
Low dose of tranexamic acid group:Loading dose: 10mg/kg (infant), 5mg/kg (children)
Infusion: 2mg/kg.h
CPB prime dose: 20ug/mL of prime volume
High dose of tranexamic acid group:Loading dose: 30mg/kg (infant), 15mg/kg (children)
Infusion: 6mg/kg.h
CPB prime dose: 60ug/mL of prime volume
Sponsors
National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients eligible for randomization were men and women aged 1 month to 12 years undergoing primary, isolated; 2. selective radical surgery for Tetralogy of Fallot; 3. Agreed to participate in the study and signed an informed consent.
Exclusion criteria
Exclusion criteria: Patients excluded from the study were those with previous cardiac surgery, preoperative hemoglobin level of <110 g/L, chronic renal insufficiency, chronic hepatic insufficiency, coagulant function abnormality, recent history of anticoagulant therapy, allergy to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total postoperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| The volume and exposure of allogeneic transfusion;The incidence of reoperation for bleeding;the maximum hemoglobin level in the first 48 h postoperatively; | — |
Countries
China
Contacts
Public ContactYu Zhang
Department of Anesthesiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed