mucosal melanoma of head and neck
Conditions
Interventions
Case series:hypofractionated radiotherapy+PD-1 inhibitors
Sponsors
Beijing Tongren Hospital, Capital Medicine University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. 100 patients with head and neck malignant melanoma confirmed by pathology were classified into stage III and stage IV according to the classification of malignant melanoma in head and neck mucosa of AJCC 8th edition. According to the pathology and genetics of head and neck tumors, the diagnostic criteria for melanoma are WHO; 2. aged 18-70 years old; 3. Stage IV includes IVA, IVB and IVC patients; 4. KPS score is above 80 points; 5. the main organs of hemogram, heart, lung, liver and kidney are basically normal. WBC (> 3.5 X 10^9/L), ANC (> 1.5 X 10^9/L), PLT (> 100 X 109/L), Hb (> 80 g/L), plasma total bilirubin (< 1.5 X), ALT, AST or AKP (< 2.5 X), urea nitrogen and muscle intoxication (< 1.25 X); 6. CT, MRI and whole body PET-CT, lymph node examination and endoscopy should be improved before admission; 7. signing informed consent, good compliance.
Exclusion criteria
Exclusion criteria: 1. there is an unexpected seizure, central nervous system disorder or loss of insight due to mental illness; 2. serious and non controllable infection; 3. main organs dysfunction (including heart, lung, liver, kidney, etc.); 4. there will be other malignancies within two years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;Local recurrence rate ;Metastasisi rate;Local remission rate ; | — |
Countries
China
Contacts
Public ContactXiaohong Chen
Beijing Tongren Hospital, Capital Medicine University
Outcome results
None listed