sepsis
Conditions
Interventions
modified early goal-directed therapy group:Fluid resuscitation was guided by 2016 Surviving Sepsis Campaign International Guidelines combined with SVV monitored by FloTrac/Vigileo system, and then req
standard therapy group:The first 6 hours of fluid resuscitation will be goal-directed by systolic blood pressure(SBP)=100mmHg and shock index (SI)<0.8.
Sponsors
Department of Intensive Care Unit The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. aged=18 years; 2. Diagnosis of sepsis refer to the definition of 2016 sepsis 3.0 and surviving sepsis campaign:international guidelines for management of sepsis and septic shock:2016; 3. definition of hypoperfusion: refractory hypotension (mean arterial pressure MAP <65mmHg) after an initial intravenous fluid challenge; 2 or blood lactate level of 4 mmol per liter or more.
Exclusion criteria
Exclusion criteria: 1. Unconsciousness caused by cerebrovascular accidents, head injury, hepatic coma, etc; 2. Combine with others types of shock; 3. Acute myocardial infarction, pregnancy, end-stage disease, extensive burns, extremely difficult mouth opening, arrhythmia, heart function level III or higher; 4. Time of spesis-induced hypoperfusion more than 24 hours; 5. Written informed consent was not obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| regional oxygen saturation (rSO2);serum S100ß concentration;cerebral extraction rate of oxygen (CERO2); | — |
Secondary
| Measure | Time frame |
|---|---|
| jugular venous oxygen saturation(SjvO2);arteriovenous blood oxygen content difference; | — |
Countries
China
Contacts
Public ContactHuang Yizhou
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed