Pertussis
Conditions
Interventions
Control group:Suggestions on diagnosis and treatment of pertussis in Chinese children in 2017
High dose group:Suggestions on diagnosis and treatment of pertussis in Chinese children in 2017 as well Intravenous infusion of ambroxol (ambroxol hydrochloride injection) at 10mg/kg per time, bid.
Sponsors
The Second Affiliated Hospital of Shantou University Medical College(Pediatrics)
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1) Typical cases are accompanied by paroxysmal and spasmodic cough, and continuous cough more than 2 weeks; 2) Atypical cases with recurrent apnea, asphyxia, purple and bradycardia, or intermittent paroxysmal cough; 3) Laboratory test is showed that peripheral blood leukocyte count and lymphocytes significantly increasing 4) Satisfy any of the above items 1 and 2, or accompany the third item, and satisfy the following items 5, 6 and 7; 5) No more than 1 year old, male or female; 6) Agreeing to cooperate with the drug according to the requirements of the test program; 7) With the informed consent of the legal guardian and the agreement of the child,then signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) Anyone who has severe respiratory failure, requiring mechanical ventilation; 2) Anyone who has congenital heart disease; 3) Anyone who has central nervous system infection; 4) Anyone who has severe renal insufficiency; 5) Anyone who has a history of liver disease; 6) Anyone who has epilepsy or febrile convulsions; 7) Anyone who has severely malnourished; 8) Anyone who has malignant tumors; 9)Anyone who has clearly allergic to the tested drugs; 10) Anyone who is treated by a testing scheme within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Integral for spasmodic cough; | — |
Countries
China
Contacts
Public ContactXiaohua Zhou
The Second Affiliated Hospital of Shantou University Medical College(Pediatrics)
Outcome results
None listed