chronic obstructive pulmonary disease
Conditions
Interventions
NIPPV+Oxygen group:Noninvasive positive pressure ventilation and family oxygen therapy
NIPPV+Oxygen+IOT group:Noninvasive positive pressure ventilation, family oxygen therapy and Internet of thing
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40 to 80 years old, male or female; 2. Clearly diagnosed patients with severe or very severe COPD: FEV1 / FVC 55%); and nasal catheter or mask oxygen therapy can not correct hypoxemia; (2) Type II respiratory failure: Arterial blood gas analysis PaCO2> 50mmHg.
Exclusion criteria
Exclusion criteria: 1. Unstable cardiac hemodynamics, such as acute left heart failure, unstable angina,etc; 2. Combined with typical pulmonary fibrosis, airway tumors, tuberculosis sequelae (lung damage) and other lung diseases; 3. Combined with neuromuscular diseases and or severe cerebrovascular accident sequelae.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severe respiratory insufficieny questionaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Pulmonary function;CAT score;mMRC score;cNAT score;6 minute walk distance and Borg score;Short term non-invasive ventilation tolerance rate;number of acute exacerbation;The number and duration of hospitalization required for acute exacerbation;The number and duration of ICU treatment required for acute exacerbation;survival rate;Hospitalization costs for acute exacerbation;ICU treatment costs for acute exacerbation;Patients' drop off rate at each visit time point; | — |
Countries
China
Contacts
Public ContactSong Yuanlin
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed