Non-inflammatory acute anterior ischemic optic neuropathy
Conditions
Interventions
Case series:Intravitreal injection of TA (1mg) one time
Sponsors
First People's Hospital Affiliated to Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged = 18 years old; 2) AION acute phase (onset =1 month); 3) OCT and / or FFA to determine active optic disc edema; 4) The visual acuity of the subject's target eye = light perception; 5) turbid medium turbidity and pupil dilation without affecting fundus examination; 6) Can sign the informed consent form and complete the follow-up observation as required. 7) Patients who have received systemic hormonal therapy and who have been evaluated by the investigator for a treatment opportunity, or who have initially diagnosed an untreated AION acute phase. Note: Each subject in the study can only be selected for one target eye. If the subject's eyes meet the inclusion criteria, the researcher will determine the target eye from a medical perspective.
Exclusion criteria
Exclusion criteria: 1) The target eye has received any intraocular drug injection therapy; 2) The target eye has a subfoveal fibrotic tissue, scar or atrophy; 3) The existing or previous eye diseases of the target eye can affect the detection of the macula or affect the central vision (obvious macular anterior membrane, vitreous macular traction, etc.); 4) The target eye has undergone ophthalmic surgery (corneal transplantation, vitrectomy, macular transposition, glaucoma surgery, laser photocoagulation, and panretinal photocoagulation), as well as other sub-macular surgery or other procedures for the treatment of CNV. ; 5) Those who have undergone cataract surgery within 3 months prior to screening of the target eye; 6) Active eye infections in the target or contralateral eye (eg blepharitis, infectious conjunctivitis, keratitis, scleritis, endophthalmitis, etc.), or systemic infectious diseases (eg syphilis, AIDS, tuberculosis) Wait). 7) Glaucoma that is uncontrollable in the past or now (the intraocular pressure is still >24 mmHg after anti-glaucoma treatment), or the gravitation/optical disc ratio of the target eye caused by severe glaucoma > 0.8, or the target eye has undergone glaucoma filtration Surgery 8) The target eye is aphagal (excluding intraocular lens) or posterior capsule rupture (except for YAG laser posterior capsulotomy after intraocular lens implantation); 9) A history of allergies to a therapeutic or diagnostic drug, or an allergic disease; 10) Diabetic patients with uncontrolled blood glucose (blood glucose = 15 mmol/L); 11) Those with high blood pressure control are not ideal (defined as blood pressure still = 180/100 mmHg after antihypertensive drug treatment); 12) A history of myocardial infarction and/or cerebral infarction within 6 months prior to screening; 13) have a clear history of other systemic history that is undergoing or require treatment, or a disease that interferes with the study (eg, tumor, organ failure, coagulopathy, etc.); 14) During pregnancy, or planning for pregnancy; 15) Merging or not excluding other optic neuropathy, retinopathy affecting visual function assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in ETDRS visual acuity compared with baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in Central visual acuity;Changes in thickness of optic nerve fiber layer compared with baseline;Changes in vessel density around the optic disc ; | — |
Countries
China
Contacts
Public ContactYuanyuan Gong
First People's Hospital Affiliated to Shanghai Jiaotong University
Outcome results
None listed