Post-stroke Aphasia
Conditions
Interventions
Intensive therapy group:3 weeks of intensive speech and language therapy.
Combined therapy group:3 weeks of tDCS over left primary motor cortex with routine speech and language therapy.
Sponsors
Shanghai Ninth People‘s Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Right-handed; 3. Chinese as first language; 4. Primary school or higher education; 5. Aphasia due to stroke (Aphasia Quotient of Western Aphasia Battery<93.8); 6. 3 weeks to 1 year post stroke onset; 7. A single infarction or haemorrhage in the left hemisphere confirmed by CT or MRI; 8. Written informed consent singed.
Exclusion criteria
Exclusion criteria: 1. Consciousness disorder; 2. Severe medical or psychiatric conditions; 3. Apraxia of speech or buccofacial apraxia; 4. Modified Rankin Score >4; 5. Severe cognitive impairment (MMSE <10); 6. With cardiac pacemaker, implanted stimulator or metal implant in the brain; 7. With a history of seizure or epilepsy hinted by EEG; 8. With severe vision or hearing impairments and uncooperative with speech evaluation; 9. With severely impaired auditory-verbal comprehension and unable to follow simple instructions; 10. With a history of alcohol or drug abuse; 11. On antidepressant or antipsychotic medication; 12. Women who are pregnant or in lactation period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in AQ of WAB from baseline to immediately after 3 weeks of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| change in AQ of WAB from baseline to 3 months later;changes in scores of I-IV part of WAB ;change in BDAE;change in CADL;change in CETI;change in language network by functional MRI; | — |
Countries
China
Contacts
Public ContactJian-Ren Liu
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed