Breast cancer
Conditions
Interventions
TP group:(Docetaxel + cisplatin)*6 cycles
TAC group:(docetaxel + adriamycin + cyclophosphonamide) *6 cycles
Sponsors
He'nan Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years old; 2. Clinical T2-T4c, or T1c with axillary LN+; 3. Three-invasive, invasive breast cancer confirmed by histopathology: Three-negative breast cancer is defined as: ER and PR negative (IHC nuclear staining =100g/L; Platelet count >=100x10^9/L; Total bilirubin = 55%; 7. Women of childbearing age were tested negative for serum pregnancy test 14 days before randomization; 8. KPS score >=80 points; 9. Informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient has evidence of metastatic breast cancer (to exclude metastatic breast cancer, thoracic and abdominal CT and bone scans should be performed at any time before diagnosis to randomization; PET/CT scans can be used as an alternative imaging test); 2. Chemotherapy, endocrine therapy, targeted therapy, radiation therapy, etc. have been accepted for this disease; 3. The patient has a second primary malignant tumor, except adequate treatment of skin cancer; 4. Because of serious, uncontrollable other medical diseases, researchers believe that there are chemotherapy contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Event free survival rate (EFS);Clinical response rate;The rate of breast-conserving surgery;Safety; | — |
Countries
China
Contacts
Public ContactZhenzhen Liu
He'nan Cancer Hospital
Outcome results
None listed