sever brain injury
Conditions
Interventions
Group 1:Intensive recruitment maneuvers
Group 2:Moderate recruitment maneuvers
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Between 15 and 65 years old; 2. The patient up to severe brain injury diagnosis standard, requiring mechanical ventilation more than 48 hours, Glasgow Coma Scale (GCS)=8; 3. Left ventricular ejection fraction >35%; 4. Lineal consanguinity or legal surrogate is willing to provide informed consent form(ICF); 5. Body mass index(BMI) < 35 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Failed to effectively control local or systemic bacterial infection in acute period; 2. With shock and critically ill patients who unable to fit the operation and effect evaluation; 3. Pneumothorax, pulmonary bulla, bronchoplaeural fistulaand had undergone lobectomy within 2weeks; 4. History of severe chronic obstructive pulmonary disease (COPD); defined as noninvasive ventilation and/or oxygen therapy at home or repeated systemic corticosteroid therapy for acute exacerbations of COPD; 5. End-stage of chronic disease; 6. Breastfeeding or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood flow velocity;28-days the incidence of pulmonary complications;28-days all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| GCS score;Mean arterial pressure (MAP);Intracranial pressure (ICP);Cerebral perfusion pressure (CPP);Oxygenation index;ICU length of stay;Mechanical ventilation time;Acute Physiology and Chronic Health Score (APACHE II score); | — |
Countries
China
Contacts
Public ContactXiangyou Yu
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed