Pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) aged 50 to 80 years; 2) total knee replacement under general anesthesia; 3) American society of anesthesiologists (ASA) grade I - II; 4) be able to communicate well with researchers and comply with the whole test requirements; 5) understand the purpose of the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) known allergy to any of the drugs or components in the program; 2) infection of the puncture site; 3) communication disorder or failure to cooperate; 4) clear past existence of cognitive impairment or mental illness (see Table 2); 5) secondary operation; 6) preoperative VAS score = 4 and lasting more than 2 weeks; 7) patients with liver and kidney dysfunction; 8) patients with peripheral neuropathy (such as diabetes mellitus, Lyme disease, uremia, porphyrin disease, Guillain-Barre syndrome) and peripheral nerve injury of lower extremity; 9) long term history of hormone use, history of chronic bronchitis, history of asthma, recent pulmonary infection; 10) chronic alcoholics (who have not been sober in the last three months); 11) to participate in other clinical trials in the last three months; 12) to have a blood coagulation disorder or haemorrhagic disease; 13) to be allergic to ultrasound coupling agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale/Score;Muscle strength grading; | — |
Countries
China
Contacts
Huashan Hospital, Fudan University