Severe Influenza A with Primary Pneumonia
Conditions
Interventions
Group A:Group A patients were given peramivir sodium chloride injection
Group B:Group B patients received peramivir sodium chloride injection and ribonucleic acid for injection II
Group C:Group C patients were treated with peramivir sodium chloride injection and thymopetidum for injection
Sponsors
Suqian People's Hospital of Nanjing Gulou Hospital Group
Eligibility
Sex/Gender
All
Age
21 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. the pharyngeal swabs of the patients were tested with nucleic acid test kits for influenza A and B pathogens, and the results showed that the patients were positive for influenza A; 2. the patients were severe cases (one of the following types of cases was considered a severe case): (1) Persistent high fever for more than 3 days accompanied by severe cough, sputum, bloody sputum or chest pain; (2) rapid breathing, dyspnea, or cyanosis lips; (3) mental changes that could include slow reactions, sleepiness, restlessness, or convulsions; (4) severe vomiting, diarrhea, or dehydration; (5) combined with pneumonia; (6) significant aggravation of previous underlying diseases. 3. the patients had primary pneumonia (excluding secondary pneumonia, CRP<20 mg/L, negative results of bacterial culture). The above three points were diagnosed as severe influenza A with primary pneumonia; 4. Patients aged 18 years old male and female.
Exclusion criteria
Exclusion criteria: (1) vaccinated for influenza within the past six months; (2) taking M2 channel blockers (e.g., amantadine, rimantadine) and neuraminidase inhibitors (oseltamivir, zanamivir, etc.) within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of virus nucleic acid positivity;The remission time of clinical symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to fever alleviation;Time to cough alleviation; | — |
Countries
China
Contacts
Public ContactHongdou Chen
Suqian People's Hospital of Nanjing Gulou Hospital Group
Outcome results
None listed