Comparison of norepinephrine, phenylephrine, and ephedrine during spinal hyptension for cesarean section in preeclamptic parturients

Evalution of efficacy and safety of norepinephrine, ephedrine, and phenylephrine for hemdynamic management in pre-eclamptic parturients during cesarean section with spinal anesthesia

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800019408

Enrollment

Unknown

Registered

2018-11-10

Start date

2018-12-01

Completion date

Unknown

Last updated

2018-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anesthesia for cesarean section

Interventions

Group 1:norepinephrine 4 ug injection for hypotension

Group 2:phenylephrine 50ug injection for hypotension

Group 3:ephedrine 4mg injection for hypotension

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: ASA I or II, singleton, non-laboring, scheduled for spinal anesthesia, and diagnosed as pre-eclampsia.

Exclusion criteria

Exclusion criteria: Diagnosed as chronic hypertension or chronic hypertension comorbid with preeclampsia; comorbid with diabetes mellitus, or cardiovascular disease; twin gestation; suspected fetus compromise.

Design outcomes

Primary

Measure	Time frame
tachycardia;	—

Secondary

Measure	Time frame
bradycardia;incidence of hypertension;number of vasopressor boluses;number of hypotensive episodes;maternal side effects;Neonatal Apgar scoring;umbilical artery blood gas;	—

Countries

China

Contacts

Public ContactShiqin Xu

Gynecology and obstetrics hospital affiliated to Nanjing Medical University

xusqnj@126.com+86 25 13951660028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026