Advanced gastric cancer
Conditions
Interventions
Sponsors
Shandong Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old, male and female; 2. Advanced gastric or gastroesophageal junctional adenocarcinoma confirmed by pathology or histology with measurable lesions and assessed as CR, PR, or SD after 6-8 cycles of first-line chemotherapy; 3. The bone marrow and liver and kidney function were normal; 4. ECOG PS 0-1; 5. The survival period is expected to be longer than or equal to 3 months. The patient has treatment indication, and no chemotherapy absolute contraindicatihon; 6. Patients can understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have been allergic to the drugs and/or their excipients required for the study; 2. Urine protein detection 2+ or above, or 24-hour urinary protein quantification >1.0g; 3. Gastrointestinal bleeding or researchers believe that the gastrointestinal bleeding may occur; 4. Patients with Abnormal coagulation function (INR>1.5, APTT>1.5 ULN), with bleeding tendency; 5. Patients with central nervous system metastasis; 6. According to the researcher's judgment, there are other serious risks to the patient's safety or the accompanying diseases that affect the patient's completion of the study; 7. Pregnant or lactating women; 8. Except for patients with contraindications to apatinib; 9. Patients considered by the doctor to be unfit for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;ORR;DCR;Safety;QoL; | — |
Countries
China
Contacts
Public ContactShu Zhang
Shandong Cancer Hospital
Outcome results
None listed