Nasopharyngeal Carcinoma
Conditions
Interventions
Group 1:CCRT + TPC
Group 2:CCRT + PF
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients with histologically confirmed non-keratinizing carcinoma (according to World Health Organization (WHO) histologically type); (2) Diagnosis with anyT N2-3M0(according to the American Joint Committee on Cancer(AJCC) 8th edition)and plasma EBVDNA=1500copies/ml; (3) ECOG Performance status =2; (4) Without prior malignancy; (5) Aged 18-65 years old; (6) Adequate liver function : Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) <1.5×upper limit of normal (ULN), alkaline phosphatase (ALP) =2.5×ULN, total bilirubin = ULN; (7) Adequate renal function: creatinine clearance =80 ml/min; (8) Adequate marrow: absolute neutrophil count =4000/µL, hemoglobin =90g/L and platelet count =100000/µL; (9) Patients must be informed of the investigational nature of this study and give written informed consent.
Exclusion criteria
Exclusion criteria: (1) History of previous radiotherapy, chemotherapy or surgery (except diagnostic) to primary tumor or nodes; (2) Diagnosis with distant metastasis at presence; (3) Pregnancy or lactation; (4) With mental, social, family or geographic factors that will affect the follow-up; (5) Participants enrolled in ongoing clinical trails; (6) Known to be allergic to potentially used chemotherapy drugs; (7) With sever infection and internal disease; (8) Any severe organ disfunction, for example, cardiopulmonary insufficiency, hepatic and renal insufficiency; (9) With factors that will affect the administration, distribution,metabolism or evacuation; (10) Using immunosuppressive agents after organ transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression Free Survival; | — |
Countries
China
Contacts
Public ContactYan-Qun Xiang
Sun Yat-sen University Cancer Center
Outcome results
None listed