Skip to content

Clinical study for inducing transplant immune tolerance to reduce/withdraw the dose of immunosuppression in living-related donor kidney transplantation patients

Clinical study for inducing transplant immune tolerance to reduce/withdraw the dose of immunosuppression in living-related donor kidney transplantation patients

Status
Recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800019341
Enrollment
Unknown
Registered
2018-11-06
Start date
2018-11-05
Completion date
Unknown
Last updated
2018-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney transplantation

Interventions

Cases:MSCs infusion

Sponsors

Organ Transplantation Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 60 years, patients with stable condition at least one year after renal transplantation and renal function can be effectively maintained by immunosuppressants; 2. There are no other new basic diseases, the patients are relatively healthy; 3. Other diseases such as blood system diseases, infectious diseases should be eliminated in living-related kidney donors and acceptors whose blood routine examination is normal; 4. Be able to comply with the research program; 5. Participate in the study and sign the informed consent statement voluntarily.

Exclusion criteria

Exclusion criteria: 1. The kidney function cannot be effectively maintained by immunosuppressants in patients with an unstable condition; 2. Patients who are taking part in other clinical trials; 3. Suffering from other basic diseases, such as: diabetes mellitus, mental neurological dysfunction, abnormal coagulation function, immune system diseases, blood system diseases, malignant tumors and other patients; 4. It's not suitable for clinical trials with other reasons.

Design outcomes

Primary

MeasureTime frame
acute rejection rate;grafted renal function;B cell and subsets;

Secondary

MeasureTime frame
urine volume;

Countries

China

Contacts

Public ContactShaoping Deng

Organ Transplantation Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital

sdeng10@163.com+86 28-87393987

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026