Androgenetic alopecia
Conditions
Interventions
A:Minoxidil group for external use
B: botulinum toxin A injection group
C:Topical minoxidil combined with injection of botulinum toxin type A
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1) Male patients with androgenetic alopecia aged 20-60 years old; (2) The diagnostic criteria for male patients with androgenetic alopecia.
Exclusion criteria
Exclusion criteria: (1) Severe mental disorders, psychological disorders, heart, lung, liver, kidney and other important organ; dysfunction, severe allergic constitution;Systemic or injection site infection, severe blood disease, anticoagulant use, etc.; (2) It is forbidden to myasthenia gravis and patients with peripheral motor nerve diseases; (3) Congenital or alopecia due to hereditary factors with complete or partial absence or dysplasia; (4) Because of endocrine dysfunction diseases, serious infectious diseases, chronic diseases such as tuberculosis, liver cirrhosis, skin diseases such as leprosy, etc.Syphilis, and other hair loss caused by drugs and trauma; (5) Complicated with other serious medical diseases, or with severe autoimmune diseases or infectious diseases; (6) Used corticosteroids or other immunosuppressive agents or immunomodulators in the past two months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Photographs were taken before treatment, 3 months, 6 months, 9 months and 12 months after treatment, and alopecia was scored according to the 7-point scale.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of alopecia: The severity of alopecia was assessed before treatment, 3 months, 6 months, 9 months and 12 months, respectively.;Evaluation of Hair Regeneration Rate: Hair regeneration rate of AGA subjects was evaluated at 3 months, 6 months, 9 months and 12 months after treatment.;The hair thickness and density of AGA subjects were measured by dermoscopy before and after treatment for 3, 6, 9 and 12 months, and the improvement was evaluated.;Subjective Satisfaction Assessment: Subject Satisfaction Assessment Scale was used to evaluate the subjects'satisfaction in 3 months, 6 months, 9 months and 12 months respectively.;The Dermatology Quality of Life Index (DLQI) was used to investigate the quality of life of the subjects, and the correlation between the quality of life and SALT score and hair regeneration rate was analyzed.; | — |
Countries
China
Contacts
Public ContactHuang Xin
Shanghai Tongji Hospital
Outcome results
None listed