Atrial Fibrillation
Conditions
Interventions
CaCl2 group:calcium autonomic denervation
Sponsors
Department of Cardiovascular Surgery, General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 18=Aged=80 years; 2. Off-pump CABG surgery not in urgent or emergent situation and without IABP or inotropes for hemodynamic support before surgery; 3. EF>40%; 4. Patients undergoing heart surgery for the first time; 5. Good compliance and ability to complete follow-up.
Exclusion criteria
Exclusion criteria: 1. With history of AF; 2. Take class I or III anti-arrhythmic drugs; 3. With history of any type AF ablation operation; 4. With history of adult congenital heart disease or significant valvular disease; 5. With history of prior heart surgery; 6. Heart surgery is accompanied by other organ-system surgery; 7. Liver and kidney function abnormality (blood level exceed the upper limit of normal value by 3 times), or with surgical contraindications; 8. Patients suffering from other diseases who require radiotherapy, chemotherapy, and long-term hormone treatment; 9. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of atrial fibrillation(lasting more than 30 seconds) during the first week of operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of hospital stay;Ventricular rate during AF;Inflammatory makers: PCT,IL-6, and hsCRP immediately after surgery;Actionable AF: antiarrhythmic use (including rate-control meds), CDV, anticoagulation, use of inotropes for BP support during AF;atrial fibrillation burden during the first week of operation; | — |
Countries
China
Contacts
Public ContactHui-Shan Wang
Department of Cardiovascular Surgery, General Hospital of Northern Theater Command
Outcome results
None listed