small cell lung cancer
Conditions
Interventions
Case series:VP-16 metronomic chemotherapy
Sponsors
Baoji Central Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Pathological diagnosis of newly diagnosed adult small cell lung cancer, including those early stage SCLC who received radical operation and adjuvant treatment relapsed for the first time after operation; 2. Patient who adapted for chemotherapy by EP regimen according to 2018 NCCN V2; 3. Aged 18-75 years old male and female; 4. ECOG score 0-2; 5. Having at least one evaluable lesion (refer to RECIST 1.1),including CT or MRI; 6. No functional disturbance of main organ and function levels meet the following criteria; (1) Blood routine examination criteria should be consistent with: ANC=1.5×10^9/L, PLT=80×10^9/L, Hb=90g/L; (2) Biochemical examination should meet the following criteria: TBIL<2×ULN, ALT, AST<2.5×ULN; (3) Renal function of serum creatinine =140mol/L; 7. Subjects voluntarily participated in this study, signed informed consent; 8. Anticipated lifetime=3 months.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumors (except for completely cured cervical carcinoma in situ or basal cells or squamous epithelial skin cancer); 2. Patients who received anti-tumor treatment before; 3. Patients with congestive cardiac failure, unstable angina, myocardial infarction, hypertension and antihypertensive medication can not be reduced to normal range, un-controlling arrhythmia or other history of heart diseases; LVEF<55%; 4. Pregnant, lactating women or those who have fertility are unwilling or unable to take effective contraceptive measures; 5. Blood sample become to coagulation or hemolysis; 6. The investigator believes that it is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cirvulating tumor cells; | — |
Countries
China
Contacts
Public ContactZhao Ya'ning
Baoji Central Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed