osteoporosis
Conditions
Interventions
Experimental group:Conventional medicines+probiotics
Control group:Conventional medicines+placebo
Sponsors
The Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients whose t-value of bone mineral density is less than -1; (2) no combined endocrine and metabolic diseases (hyperthyroidism, Cushing's syndrome, hypogonadism, hyperthyroidism, pituitary prolactin tumor, diabetes (mainly in type 1 diabetes and part of type 2 diabetes), and hypophysis); Connective tissue disease (systemic lupus erythematosus (sle) and sjogren's syndrome, dermatomyositis, mixed connective tissue disease), a variety of chronic kidney disease causes renal osteodystrophy, gastrointestinal disease and nutritional diseases (malabsorption syndrome, gastric bowel resection most, chronic pancreatic diseases, chronic liver disease, malnutrition, chronic venous nutrition support treatment), and blood system diseases (leukemia, lymphoma, multiple myeloma and abnormal bone marrow proliferation syndrome), neuromuscular system disease (of hemiplegia caused by various reasons, paraplegia, motor dysfunction, muscular dystrophy, jiang syndrome and myotonia syndrome), brake for a long time Or patients with osteoporosis after space travel, organ transplantation, drugs and poisons (immunosuppressants, heparin, anticonvulsants, cancer drugs, aluminum antacids, thyroid hormones, chronic fluorosis, gonadotropin releasing hormone agonist (gnrh-a) or renal failure dialysis).
Exclusion criteria
Exclusion criteria: 1. Secondary osteoporosis (with endocrine metabolic disorders, connective tissue disease, a variety of chronic kidney disease causes renal osteodystrophy, gastrointestinal disease and nutritional diseases, blood system diseases, diseases of the neuromuscular system, brake for a long time or space travel, organ transplantation, drugs and poisons;) in patients with osteoporosis; 2. Active stage of peptic ulcer; 3. Patients with malignant gastrointestinal neoplastic disease; 4. Previous cases of lactose intolerance, irritable bowel syndrome, inflammatory bowel disease, habitual diarrhea and other intestinal diseases; 5. Patients with infectious diseases need to be treated with antibiotics; 6. Have a history of allergy to lactobacillus and its products or a hypersensitive constitution; 7. Other researchers consider it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density; | — |
Countries
China
Contacts
Public ContactZhao Jianmin
The Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed