schizophrenia
Conditions
Interventions
Group 1:Tiaoweichengqi Decoction and placebo tablet
Group 2:Metformin and palcebo decoction
Sponsors
Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Comply with the International Classification of Diseases (ICD-10) diagnostic criteria for schizophrenia; conform to the stomach of Chinese medicine internal medicine Heat and phlegm type syndrome differentiation and treatment; 2. The patient takes olanzapine at a dose that amounts to the minimum and above therapeutic amount of the drug; 3. Meet the clinical diagnostic criteria for the metabolic syndrome of the Chinese Medical Association Diabetes Branch; According to the 2004 Chinese Medicine Recommended Diagnostic Criteria for Learning Diabetes Branch: 3 or all of the following 4 components: (1) Overweight and (or) Obesity: BMI = 25.0 (kg / m2); (2) Hyperglycemia: FPG = 6.lmmol/L (110mg/dL) and/or 2hPG = 7.8mml/L (140mg/dL) and/or have been diagnosed with diabetes and treated; (3) Hypertension: SBP/DBP=140/90mmHg and (or) diagnosed hypertension and treated; (4) dyslipidemia: fasting blood TG = 1.7mmo/L (15Omg/dL) and / or fasting Blood HDL-C <0.9 mmol/L (35 mg / dL) (male), (1.Ommol/L (19mg/dL) (female). 4. male and female aged 18-60 years old; 5. Provide informed consent to participate in the study, signed by the subject or legal guardian.
Exclusion criteria
Exclusion criteria: 1. with serious physical diseases, brain organic diseases, craniocerebral trauma, etc.; 2. Those with acute infections; 3. Patients with acute complications such as diabetic ketoacidosis, or other cardiovascular and cerebrovascular diseases (such as myocardial infarction, Infarction, cerebral hemorrhage); 4. Severe primary liver and kidney diseases, mental patients, pregnant or lactating women, and those who are allergic to this drug; 5. Blood pressure > 160/95 mmHg. 6. Patients who meet the International Classification of Diseases (ICD-10) diagnostic criteria for alcohol, drug dependence, and mental retardation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMI;blood sugar;TG;leptin;HDL;blood pressure;T CM syndrome scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood concentration of olanzapine;CGI;PANSS;SF-36;PSP;RBANS; | — |
Countries
China
Contacts
Public ContactLiping Zhu
Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center
Outcome results
None listed