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Effect of continuous infusion of cis-atracurium with different doses during clipping of intracranial aneurysms on motor evoked potential monitoring

Effect of continuous infusion of cis-atracurium with different doses during clipping of intracranial aneurysms on motor evoked potential monitoring

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800019246
Enrollment
Unknown
Registered
2018-11-01
Start date
2018-12-01
Completion date
Unknown
Last updated
2018-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intracranial aneurysm

Interventions

1:Continuous infusion of 0.075mg/kg.h CIS atracurium
2:Continuous infusion of 0.1mg/kg.h CIS atracurium
3:Continuous infusion of 0.125mg/kg.h CIS atracurium

Sponsors

Department of Anesthesiology, West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing aneurysm clipping and motor evoked potential monitoring in West China Hospital; 2. ASA I-II; 3. Aged 18-60 years; 4. Normal liver and kidney function; 5. Intraoperative use of total intravenous anesthesia; 6. Preoperative use of antibiotics, antiepileptic drugs and other drugs affecting muscle relaxants.

Exclusion criteria

Exclusion criteria: 1. BMI > 30; 2. Water electrolyte disorders; 3. Severe anemia and malnutrition; 4. Predicted difficult airway patients; 5. Temperature abnormalities; 6. Postoperative ICU treatment, unable to extubate patients; 7. Pregnant and lactating patients, with neuromuscular disease.

Design outcomes

Primary

MeasureTime frame
Motor evoked potential monitoring success rate;—

Secondary

MeasureTime frame
Motor evoked potential Stimulation intensity;—

Countries

China

Contacts

Public ContactLi Yu

Department of Anesthesiology, West China Hospital, Sichuan University

biaojieli@tom.com+86 18980601545

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026